Has anyone heard of "Palladia" as a chemotherapy drug for mast cell tumors?


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Clovis Boo Flynn and Gary avatar image

Has anyone heard of "Palladia" as a chemotherapy drug for mast cell tumors?

I am in shock as I write this. Clovis's lab report is not good. She has a Grade III mast cell tumor that is poorly differentiated. Grade III is the worst of the three grades. My vet said, however, that there is a new chemotherapy drug called Palladia that has had good results. Is anyone familiar with Palladia? Thanks.

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Angela and PollyAnna's picture

OH NOOO!

We just love Clovis! Hope every thing is going to be OK!!

Its a bullie thing...
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Very sorry to hear this Gary

Please give Clovis hugs from me and my thoughts and prayers are with you.

Clovis Boo Flynn and Gary's picture

It was on her right hip, but was surgically removed

about three weeks ago. The biopsy report says that it "appears" that the tumor was completely excised. But Clovis also has the worst grade, a Grade III.



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Clovis Boo Flynn and Gary's picture

Thanks for the article

I'm hoping the free trials are still available.



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Clovis Boo Flynn and Gary's picture

Thank you so much for those links

and especially for Pfizer's phone number.



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Clovis Boo Flynn and Gary's picture

Thanks, but I think that giveaway program is over

from what I have read, it ended in December, but I will still double check. Thanks again.



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Prayers

+

prayers for you & clovis

hope this new drug works

[linked image]

Gary.....I love Clovis and will keep you all in my thoughts.

nm

some links

I don't have any experience with the drug, but being a Pharmacist I had to look up what it was..

http://www.nevog.com/news/14/palladia_the_new_drug_from_pfizer

http://vetmedicine.about.com/b/2009/06/03/palladia-new-anti-cancer-drug-for-dogs.htm

Or you can contact Pfizer at:

http://www.pfizerah.com/Webmastermail.aspx?country=US=EN&species=OO&drug=PU
1-800-366-5288


I saw a few sites that were asking for dogs with mast cell tumors to be in a trial, I'd question Pfizer about this to see if there is anything close to you like this. The drug is pretty new so you never know.

The drug looks promising but I'd question what other options are and what their success rate are. They claim this is the only drug specifically for dogs but human drugs have been used in dogs and I'm sure there is data on their effectiveness and side effects in dogs.

Positive thoughts to you and Clovis.

~Jen (and Sass)




ramfanshan's picture

Gary....I have no input on the drug.....

...but you and Clovis will be in our thoughts...we will be sending all of the good vibes and mojo we have to you guys....give her a butt scratch for us.....and the others too....

The Wrinkle Ranch




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Sue-Bear's picture

Gary

So sorry to read this. Sending thoughts and prayers to you and Clovis




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Buddy and Karen's picture

omg Gary!

I had no idea you guys were going through this.
Sorry, I have no idea what the drug is but sending lots of positive
vibes your way.


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RosieBeGood's picture

Sending good thoughts your way!

I had to deal with MCT in Rosie and it was the hardest thing I have ever done! I am sending strong prayers your way! I never heard of that treatmetn it was not mentioned about 2-3 years ago when Rosie had hers but I will be praying that it is a good thing!

[IMG][linked image][/IMG]

[IMG][linked image][/IMG]

Oh Gary...:(

I am not overly familiar with this type of cancer or the drugs used to treat them. I would make drastic diet changes immediately and involve a holistic vet as well.
I wish Clovis a full recovery.

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Monica-Maude-Gus's picture

Gary - No knowledge to share but plenty of prayers for Clovis

And you and the rest of your family. I am just in shock from this news. I hope you get some good information from some of the other folks on the board.

lotus8305's picture

So so sorry keep the faith .....

Hang in there

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Alicia Jay Deuce and Oliver's picture

So sorry to hear about Clovis....

Sorry I can't help you with the medication question but I will for sure be sending good thoughts for you and Clovis.

found a reuters article.

http://www.reuters.com/article/idUSN037678920090603


UPDATE 2-FDA approves Pfizer cancer drug for dogs
Wed Jun 3, 2009 1:14pm EDT
Stocks



* Palladia approved for canine mast cell tumors

Stocks | Regulatory News | Global Markets

* Pfizer to begin selling drug in early 2010

* First cancer treatment specifically designed for dogs (Adds therapy details, no comment on price)

By Bill Berkrot

NEW YORK, June 3 (Reuters) - Pfizer Inc's (PFE.N) efforts to develop new cancer drugs have yielded a breakthrough -- for dogs.

The U.S. Food and Drug Administration has approved the first cancer treatment specifically designed to treat dogs, Pfizer and the agency announced on Wednesday.

The drug Palladia was approved to treat canine mast cell tumors, a potentially serious type of cancer that accounts for about 20 percent of canine skin tumors, and one that can spread to other parts of the body, including lymph nodes, if not treated.

All cancer drugs now used in veterinary medicine originally were developed for use in humans and are not specifically approved for use in animals, the FDA said.

"This cancer drug approval for dogs is an important step forward for veterinary medicine," Bernadette Dunham, director of FDA's Center for Veterinary Medicine, said in a statement.

"Prior to this approval, veterinarians had to rely on human oncology drugs without knowledge of how safe or effective they would be for dogs," she said.

Pfizer said it would begin selling Palladia in early 2010, but will make the oral drug available to certain veterinary oncology specialists prior to that.

Palladia works by killing tumor cells and by cutting off the blood supply to the tumor.

The pill must be taken every other day and the dog will likely have to be on the therapy for several months or longer, depending on tumor response, Pfizer said.

Pfizer declined to divulge the cost of the treatment or to forecast what annual Palladia sales might be. The world's biggest drugmaker said it will likely announce the price of the drug sometime this summer.

Treatment with new cancer drugs for humans tends to cost tens of thousands of dollars per patient, and the majority of pet owners do not have health insurance for their dogs.

In clinical trials, some 60 percent of dogs treated with Palladia, known chemically as toceranib, had their tumors disappear, shrink or stop growing, Pfizer said.

Pfizer Animal Health estimates 1.2 million new canine cancer cases are reported in the United States every year.

Pfizer shares fell 14 cents, or 0.9 percent, to $14.84 in afternoon trading on the New York Stock Exchange. (Reporting by Bill Berkrot, editing by Matthew Lewis, Richard Chang)

bulldogs ehh!

AmyandSophia's picture

I don't know anything about it Gary but I will be praying for yo

Poor Clovis. I am so sorry this is happening to her. Many prayers for her.

Amy and Sophia

Gary

Im very sorry to read this. my thoughts are with you.

LDeLeo's picture

Gary I am so sorry to hear this. I am going to the vets this mor

what they know about it.

Caroline-Mack-Stella's picture

gary

i'm so sorry you and clovis have to go through this. i will be sending many good thoughts your way.

[linked image]

Oh, Gary,

I'm sorry to hear this. Lots of prayers for you and sweet Clovis.

flbulldogmom's picture

I was so sorry to hear about Clovis

I forwarded your post to a boxer friend who has gone through a similar situation, only her dog's tumor is in his head, they did chemo and a new drug too - will keep ya posted when I hear back from her

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Tammy-Bailey-Ellie's picture

No! Gary, this terrible news.

Sending so many prayers to Clovis and keeping my fingers crossed this is a wonderful drug.

I do have a friend who's bulldog has had 2 mast cell tumors (not sure what grade) but he is doing great.

sad.gif

http://www.youtube.com/user/TThresh

NO..idea..but wil keep you in my thoughts Gary..soo sad..

this is very very sad news
to start off the new year..
will keep CLOVIS in my thoughts you and you too
cancer is a terrible..for anyone...person or animal alike..
my thought are with you

michelle_muse's picture

I will be sending healing prayers for sweet Clovis

and strength for you, Gary.

Michelle, Helen, Penny, Spanky and Faye pup

Cheryl and Atlas's picture

Oh no, Gary...

I am so sorry to hear that. I hope you find something to fight it. You and Clovis are in my thoughts and prayers. Stay strong. Hugs and well wishes to Miss Clovis.



Cheryl & Atlas

Gary - I'm very sorry to read this...

Keeping Clovis in my thoughts and prayers.

Olivia/Kano/Q-Ball
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:( so sad to hear this

I hope you can find some more info for this drug.


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KIM AND DUNCAN's picture

don't have any info...

but sending prayers for Clovis. Sorry to hear!

No clue Gary..

But will keep that extra special girl in my thoughts and prayers... what a shock.

My Flickr pics..
http://www.flickr.com/photos/christietillie/

Always in my heart...
Our Tillie

Lonna with Harley and Raven's picture

Sorry to hear the news was not better ):

I am not familiar with mast cell tumors or their treatment but sounds like your vet is trying the best path available. Will be thinking of you and Clovis and hoping for a full recovery!

Kathy Chester Newman and Jessa's picture

Gary, so sorry to hear that...

I haven't heard specifically of Palladia but I know chemo can do wonders for these cancers. Are you going with your vet or do you have an oncologist that can treat her? They didn't give us a grade on Ollie MCT but the vet said it was non agressive and slow growing, so no chemo for him, just surgical removal. Prayers coming for Clovis.

Kathy, Ollie and Chester

Céline and Angel Stella's picture

Oh Gary!

I guess I missed a lot during my two weeks away from BDW. Where does Clovis have a tumor. Is it operable.

When I was going through the whole eye thing with Stella, we considered many chemotherapies (although her tumors weren't actually cancerous) and we ended up trying one (it wasn't palladia - it was called lomustin). But I did do a lot of reading on the subject and there seems to be some really great progress with treatment using chemo for dogs. Stella had absolutely no reaction to the drug at all, no tummy upset, nothing!

Withing all the best for you and "our" girl.

Tomoko's picture

Gary... I'm sorry to hear about Clovis' patho result

but please think positive!

My cancer was diagnosed as Grade 3 (worst) endometrial carcinoma almost 4 yrs. ago and I'm still alive with no recurrence or metastasis, even though I only had surgery alone ( I refused chemotherapy or radiation).

We are sending tons of good thoughts and prayers to you and Clovis.

Tomoko & Gumpooh

We are keeping you and Clovis in our prayers...

Oh Gary, I'm sorry Clovis

got such a fearful report. But, I pry that Palladia is in fact the "miracle" our precious girl needs.

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Cathie Chopper and Stitch's picture

"Good results" is promising

Positive thoughts for Clovis and hoping for the best.

Dawn.Stryker.Jayda's picture

I haven't heard of it.

Sending many good thoughts & prayers for Clovis. 

Dawn~Stryker~Jayda
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bulldogmomma2's picture

no idea:( but thinking of you..

and Clovis..hoping you can beat this..so sorry to hear this news...

much bully love~Christine, Dupree, Marley and Savannah

MaggieMozeOllie's picture

I am thinking of Clovis and her daddy...chemo is her best chance

eradicate the tumor. We have lost two dogs to mast cell tumors that were operated on, but came back quickly. I will say extra prayers for her to improve and beat this thing. Hugs to you both,
Maggie, Moze, Ollie, and their dad

Maggie, Moze, Ollie,
...and always Schubert
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CathyandAudrey's picture

Oh no!

Clovis! I am sorry Gary. I don't know anything about it, but I hope it works wonders for Clovis.

Cathy
when she first came home
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Janice Toby and Betsy's picture

Oh no, I am sorry to hear about Clovis

I know nothing about treatment, but wanted to let you know, Gary, that Clovis is in my thoughts. I hope you can find a good treatment for her.

Janice

Oh Gary, I'm so sorry to hear this.

what a shock for sure, poor Clovis. my thoughts n prayers are with you. lets keep our fingers crossed that the Palladia will work miracles on Clovis!

jean n duncan

Carol Diana Fergie Ollie and Chance's picture

No, but prayers for her for sure. I

will check with my vet and a few others who I know have had experience with mast cell tumors. They are not bulldoggers, but I will see anyway.

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