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4th day in ICU - neurological issue unclear. Possibly Encephalitis or Lymphoma

4th day in ICU - neurological issue unclear. Possibly Encephalitis or LymphomaHoping for some help or direction. Our 2.5 year old english bulldog Jaxson had what appeared to be a seizure Thursday night (July 28th) and 4-days later is still in ICU with cause unknown. Will try to give as much detail as I know. Suggestions, own experience, help would be greatly appreciated. (for history of Jaxson please go to @Jaxsonthebulldog on instragram -https://www.instagram.com/jaxsonthebulldog/

Jaxson has been fighting what we thought and were told by the vet (and a separate visit to the hospital) was a middle ear infection for the past two months. Concerned, we followed up with vet visits regularly. Prognoses was always that he had a middle ear infection. During this time he has been on antibiotics, antinausea, steroids, naturopathic drops, and Vitamin B injections. Some days were better than others, but the basic symptoms included, 
-head tilting to the left
-lethargic
-loss of balance at times
-loss of appetite
-weight loss
-depressed/disconnected
-occassional moaning

Thursday evening Jaxson appeared to be agitated/wouldn't keep still, pacing back and forth and breathing heavily. We attempted to give him water, but he wouldn't drink it. I picked him up and when I placed him on the floor his front paw was beneath his belly and he couldn't seem to get up from that. He then panicked and started having what appeared to be a seizure.
Panicked, I drove him to an emergency hospital.

Jaxson went into ICU immediately. Electrolytes were low (better now). Wet him and put ice packs underneath him to cool him off. Gave him Valium and put him on IV. He has since had x-rays, blood work, MRI and a spinal tap done. 
-x-rays good
-blood work came back good with slight elevated numbers in his liver, but so small it was okay. 
-spinal tab showed 0 count on white blood cells (the norm is 0-4)
-MRI showed an irregular area in the right brain stem and an irregularity in the right medulla.

Bit of a mystery as to what the underlying cause is.

In the front part of the brain there are fluid chambers called ventricles. His are quite large. Neurologist is not putting too much weight on this because most bulldogs can have large ones. If they are big it can be a disease called Hypersephalus - these normally can develop signs at 1-year of age. Jaxson will be 3 in October.


What specialist did see in the MRI that shouldn't be there was an irregular area of brain in the right brain stem. In the right medulla. That will explain why he's delayed to correct the paw-claw correction test. 
The only other thing they saw that's irregular in the brain was on that same side in the cerebellum (sits right above the medulla). But that won't cause the dull and circulating to the right, which he does do sometimes recently.
Dull, pacing, circulating - these are usually symptoms of the front brain.
-Encephalitis is inflammation of the brain, but his spinal tap was normal, no elevated white blood cells.
Middle-inner ear seemed ok on MRI
The other consideration is Lymphoma in the brain, but this usually has high white cell count and targets older dogs. 
-They see dysfunction in an area of the brain, but struggling on the underlying cause. The diagnostics do not fit nicely with the dysfunction.

Can anyone please help? The worse part is not knowing.
thank you in advance.
mdr
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@jaxsonthebulldog

I am so sorry you are going through this with your boy.

I don't have any ideas,  but I will be sending lots of prayers that you will get some answers soon.  Prayers for Jaxson.

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Any new news?

I've been thinking about Jaxson.

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Kathy Chester Newman and Jessa's picture

Poor baby...

sending good thoughts his way.  Those symptoms to sound neurological, I take it they've ruled out any kind of brain tumor.  Our boy Oscar developed lymphoma at 5, but his white count was through the roof even though he had no symptoms except for enlarged lymph nodes in his neck.  Please keep us update on what happens.

jaxsonthebulldog's picture

Jaxson spent 5 days in ICU.

Jaxson spent 5 days in ICU. On the following day they removed him from IV and were going to move him into a ward (cage) with occassional monitoring, so I asked to bring him home for a few days.  He has improved a bit, in that he has not had seizures in the past few days and is moving around a bit. The doctor put him on prednisone and wanted to see him in a week.

We went in on tuesday for his one week appointment - it was discouraging. Neurologist is still baffled, aside from the masses that appeared on the MRI, all other tests were positive, so unable to pinpoint the root of the problem. we are told he hasn't had a stroke. He is to continue the prednisone for another week to see if there is any change, and another MRI to be done in 3-weeks. Meanwhile, the uncertainties - the falling over, confusion, unresponsiveness, lack of appetite, and staring off at walls still continue. We are afraid to have him climb or go down stairs on his own.  Sometimes it looks as though he's forgotten how to drink water.

Any input/direction would be greatly appreciated.

Thank you for all your positive thoughts.

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@jaxsonthebulldog

Poor guy. I hope you can find some answers soon.

It is so hard to see our furbabies sick or hurting.  Do you have any vet schools near you?

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jaxsonthebulldog's picture

No Vet schools that I know

No Vet schools that I know of, but he does have a neurologist looking into what it could be. I Wish I had better news, but still no significant improvement in Jaxson. We have noticed that his lower right side of his jaw hurts when touched, not sure why. We are trying to get him in to see the neurologist earlier than his next scheduled appointment of August 30th. Not knowing is so difficult and prolonging his pain.
https://www.instagram.com/jaxsonthebulldog/

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@jaxsonthebulldog

I think about him often.

Please keep us updated.  Sending positive thoughts your way.

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